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We thank our participants and the coordinators of the University of Pittsburgh Asthma and Environmental Lung Health Institute at the University of Pittsburgh Medical Center for their patient recruitment and management

Disclosures: Nicole Kim: Madrigal: Grant/Research Support, Muyi Li: Nothing to Disclose, Philip Vutien: Nothing to Disclose, Joleen Borgerding: Nothing to Disclose, Abbey Barnard Giustini: Nothing to Disclose, Kay Johnson: Nothing to Disclose, Kristin Berry Wyatt: Nothing to Disclose, Catherine Mezzacappa: Nothing to Disclose, Tamar Taddei: Nothing to Disclose, David Kaplan: AstraZeneca Inc: Grant/Research Support, Roche Genentech: Independent Contractor, Exact Sciences: Grant/Research Support, Glycotest: Grant/Research Support, Sirtex: Advisor, Exelixis: Advisor, AstraZeneca: Advisor, George Ioannou: Nothing to Disclose 1838 THE CHEMOPROTECTIVE EFFECTS OF GENISTEIN IN A RAT MODEL OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA Maneerat Chayanupatkul 1 Duangporn Werawatganon 2 Natcha Wanpiyarat 2 , 1 Faculty of Medicine, Chulalongkorn University, 2 Chulalongkorn University Background: Liver cancer is the sixth most common cancer and the third most common cause of cancer-related mortality worldwide