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However, if the UPR is overwhelmed or prolonged, it can trigger cell death pathways, highlighting the delicate balance between cellular survival and demise under ER stress conditions

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b qua tham s khng r |lay-url= (tr gip) Molecular and Cellular Endocrinology

It is therefore plausible that the upregulation of Bmal1 and the modified activation of the negative feedback loop, which takes place in all brain areas, acts as a counterbalancing mechanism to the neurodegenerative effect