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doi: 10.1083/jcb.152.5.1071

Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation

The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior

Daily supplementation may need to be continued, but cobalamin blood levels could be monitored with less frequent dosing to see if decreased frequency of administration is adequate