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Confronted with severe serotonin syndrome, gastric pentadecapeptide BPC 157 ( with no behavioral or temperature effect of its own) has a beneficial activity, which is likely to be specific and related to a rather specific counteraction of 5-HT2A receptors phenomena [24]

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BPC-157's NGF upregulation in enteric neurons could theoretically restore normal vagal signalling over time, which is why gastric emptying improvements in animal studies persist beyond the peptide's plasma half-life (approximately 4 hours subcutaneously)