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Specifically, 5-amino-1MQ and 7-amino-1MQ exhibited high passive and active transport across membrane, with no detectable efflux observed in the Caco-2 cell assay

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Studies have shown that knocking down the NNMT gene leads to increased expenditure of energy in adipocytes (Xu et al., 2022)

Gastrointestinal side effects such as nausea, abdominal discomfort and/or diarrhea should be monitored closely

21, 23 Consider supplementation when the patient is prescribed medications causing folate deficiency, e.g., methotrexate