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Not FDA-approved and associated with significant safety concerns including dangerous nausea, uncontrolled melanocytic changes (nevi/moles), hypertension, and priapism

The melanotic macules are usually brown, deep blue/black, or black, and they are well circumscribed with sharp, delineated borders

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Skin cancer on the foot, or pedal melanoma, is fairly rare in people with white skin

In nongingival locations, the pigmentation tends to be irregularly-shaped with less defined borders [6]

Aetiological factors for penile SCC are similar to those for PIN, including increasing age, presence of a foreskin (neonatal circumcision reduces the risk), phimosis, chronic inflammatory genital disease (mostly penile lichen sclerosus), smoking, treatment with photochemotherapy (psoralen and ultraviolet A [PUVA] therapy), multiple sexual partners (with earlier onset of sexual activity) and immunosuppression