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This effect is notably reduced in adipocytes from obese individuals, suggesting that impaired cGMP signaling may contribute to the insulin resistance observed in T2DM

This might be particularly relevant in activities such as phagocytosis, where cells ingest harmful particles, and inflammation, a critical response of the immune system to infection and injury

doi: 10.1111/j.1572-0241.2003.07385.x

Solution : To enhance protein stability, it is essential to use gentle purification conditions and include stabilizing agents in buffers, such as protease inhibitors or stabilizers