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Indications: Guanethidine is no longer available in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)

Moreover, comparing the oxidative-resistant abilities between BP@CeO x and MBC, the results indicated that BP@CeO x showed a higher ROS clearance ratio during the first 4-day co-incubation period via directly exposing amounts of active sites to consume ROS in the environment (Supplementary Fig