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Yi et al., 2008), and increase BDNF (Weng et al., 2016)

Additionally, methylation plays a crucial role in epigenetic modifications, which can alter the expression of genes without changing the DNA sequence

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AGE accumulation due to diabetes and diet The slow turnover rate of collagen molecules within tendon makes it a tissue particularly susceptible to excess free glucose associated with hyperglycemia, as seen in diabetic patients, and it may induce excessive AGE accumulation at more dramatic rates than healthy counterparts (Brennan, 1989

For instance, in tendon cells it activates the FAK-paxillin pathway to increase cell movement and adhesion for repair [6]