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Alone this line, several compounds targeting UCHL5 and USP14 have been developed, including b-AP15 (Wang et al., 2016), AC17 (curcumin analog) (Zhou et al., 2013), and various metal-based complexes (Liu et al., 2014b

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The company must also hire an expert to review their drug products and receive written permission from the FDA before resuming distribution of them.