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Its activation promotes the release of proinflammatory cytokines such as 1 L-1 and IL-18 and induces pyroptosis, leading to endothelial injury and TF release, thereby fueling thrombo-inflammation

Expression and characterization of human glutamatecysteine ligase

10.1002/ana.22593 130 MagliozziR.HowellO

however, recent data suggest that GSH might have an important role in this process

It can be speculated that the PI3K/Akt/mTOR signaling pathway may lead to LPS-induced intestinal barrier damage through autophagy and regulatory protein synthesis

These GTE polysaccharides suppressed the intracellular levels of reactive oxygen species (ROS), as well as elevating antioxidative enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH)