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Estrogen may play a role in low flow POTS by decreasing renin levels, decreasing ACE activity and thereby increasing BKN, decreasing AT1 receptor density and decreasing aldosterone (Ma et al., 2021)

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Tumor microenvironmental physiology and its implications for radiation oncology.Semin Radiat Oncol

In addition, compared with lean mice, obese mice have been shown to have lower Mn levels in various tissues, such as the liver, small intestine, and bone 249

These properties all may benefit those who suffer from AFS