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Excessive apoptosis, glycolysis, and abnormal levels of gluconeogenase in rheumatoid arthritis involves in the dysregulation of glucose metabolism: an animal model study

In vivo , intravenous injection of CRC cells into non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice showed that curcumin prevented lung metastasis formation in a miR-34a-dependent manner, suggesting curcumin induces mesenchymal-to-epithelial transition (MET) (27)

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The observed conflicting results across various trials, such as those for GCs and G-CSF, highlight significant heterogeneity within patient populations, variations in disease severity at presentation, and inconsistencies in trial design