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Sorafenib has been established as a first-line oral systemic therapy in the treatment of hepatocellular carcinoma, demonstrating significant survival benefits in advanced-stage disease

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Kim KA, Kim D, Kim JH, Shin YJ, Kim ES, Akram M, Bae ON (2020) Autophagy-mediated occludin degradation contributes to blood-brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models