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doi: 10.1530/eje.0.151s011 20 AdamsTEEpaVCGarrettTPWardCW

Negative correlations between the activity of complex II + III and DCFH-DA concentration in both salivary glands suggest, on the one hand, that reduced activity of this complex entails the increased generation of mitochondrial ROS

Pyruvic acid production from alanine and lactate can also occur in the mitochondrial matrix

doi: 10.1104/pp.106.078204 148 RizhskyL.LiangH.MittlerR

Research has also found that impairment of the glutamate metabolic pathway can also lead to increased depression-like behavior (Lee et al., 2013)

The OIS phenomenon, however, may be the rationale for the lack of progression of PA to higher-grade tumors, in the absence of additional cooperating mutations (59)