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The central idea is that modern life exposes us to far more environmental stressors than our systems were built for, and that accumulated burden interferes with normal function

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doi:10.1371/journal.pone.0240584 Elia J, Wilson Z, La Porta LS, et al

Extended ATX supplementation, spanning a period of 8 months, led to a partial reversal of Erastin-induced alterations in human LECs from ARC models, which included the suppression of GPX4, an accumulation of ROS, and a decline in mitochondrial membrane potential (144)