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CRISPR-mediated deletion of CD44 Bone marrow cells were isolated from TC1 mice and haematopoietic stem cells were enriched using an EasySep Mouse Hematopoietic Progenitor Cell Isolation Kit following the manufacturers instructions (STEMCELL Technologies, 19856 A)

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While CFTR may be one of the only known apical transporters of GSH in the lung, the present studies show that there is still an increase in ELF GSH with the hypertonic saline treatment in the CFTR KO mice, although not nearly to the same degree as the WT suggesting other apical GSH transporters

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Mechanistic plausibility is largely theoretical pending human confirmation