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This article delineates the mechanistic interplay in PD between S pathology, sirtuin dysregulation, and impaired insulin signaling, illustrating how systemic metabolic dysfunction may contribute to the progression of neurodegeneration

ChemMedChem 11:11611171 Mathew B, Mathew GE, Uar G, Baysal I, Suresh J, Vilapurathu JK, Prakasan A, Suresh JK, Thomas A (2015) Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: synthesis, biochemistry and molecular docking studies

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This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)

According to William Morton, M

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