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Furthermore, melatonin-induced changes in glycosaminoglycan production may impact the TM, which regulates IOP, potentially influencing the pathophysiology of POAG (81)

5.6 Cerebrovascular diseases Interestingly, several studies have reported promising effects of pepper family derivatives in case of ameliorating risk factors for cerebrovascular diseases and reversing the outcomes such as neural damage

Although the precise prevalence of painful peripheral neuropathy in cirrhosis remains elusive, research has revealed that 15% of cirrhotic patients manifest neuropathic symptoms such as numbness and paraesthesia ( 10.3 Treatment and adjunctive management General principles include addressing comorbid symptoms (such as sleep, mood, memory, fatigue, and psychiatric disorders), emphasizing self-management tools, and employing multimodal therapies that combine several non-pharmacologic strategies

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10.1002/cjoc.20010191206 93 PengZ.ZhangC.YanL.ZhangY.YangZ.WangJ.et al (2020)

Experiments showed that rhodioloside treatment (10, 25, 50 M, administered 24 h prior) increased cell survival rates while reducing intracellular ROS levels