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There are several specific concerns: Unknown long-term effects - Licensed medicines undergo years of trials and post-market surveillance

The interest is legitimate and the animal data is compelling, but intellectual honesty requires acknowledging that compelling animal data has failed to translate to human benefit in many prior pharmacological contexts

In a review of studies, researchers found that while vitamin B12 supplementation did not improve depressive symptoms, low vitamin B12 levels were linked to an increased risk of developing depression

JAMA Surg 159(9):1087-1089, 2024

In such cases, our healthcare professionals may recommend Vitamin B12 injections

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