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JAMA 315 , 24242434 (2016)

Using multiplex imaging combined with spatial transcriptomics, we demonstrate that the response to hypoxia is durable for a subset of genes that we term the HM even after the cells are reoxygenated to the physiologic O 2 concentrations of breast tissue

Collectively, mitochondria as the primary generators and the recipients of oxidative damage, implies a vicious cycle wherein impaired mitochondria produce increased amounts of ROS, in turn leading to a progressive accumulation of damage that culminates in the process of aging (Figure 1)