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Given that many DNAm sites are co-methylated, we computed MRS scores using coefficients from the elastic net model which considers multiple CpGs jointly (Methods), rather than using coefficients from robust linear models, which were fitted to data for each CpG independently

For instance, AuNPs could be functionalized with drugs or targeting molecules and used for targeted delivery of drugs or as contrast agents for imaging

Structure and Functions of mTORC1 The protein serine threonine kinase TOR (target of rapamycin) was initially identified in Saccharomyces cerevisiae as a target of the macrolide fungicide rapamycin and later, the mammalian counterpart was identified and named mammalian/mechanistic target of rapamycin (mTOR), also known as FRAP (FKBP12-rapamycin-associated protein), RAFT (rapamycin and FKB12 target), and RAPT1 (rapamycin target 1) ( mTORC1 is composed by the regulatory-associated protein of mTOR (Raptor), a scaffolding protein important for mTORC1 assembly, stability, substrate specificity and regulation (Figure 1)

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