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Secondly, the optimal route of administration, dosage, and timing of stem cell therapy still need further exploration

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Another phase 1 study reported that vitamin D is well tolerated in patients with ALD when achieving the target plasma 25-hydroxyvitamin D level [91]

Early clinical experiences with implanted insulin-producing cells suggest that restoration of functional -cell pools is feasible, but broad implementation will depend on overcoming barriers related to immune protection, standardization of cell manufacturing, and long-term safety and maturation of grafted cells