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MSCs could reduce the production of inflammatory factors such as IL, TGF, TNF and interferon (IFN), inhibit the proliferation of T and B cells, reduce IgG secretion, inhibit the maturation of dendritic cell and regulate the activities of other immune cells such as natural killer cells and macrophages (214)

Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance

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