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In addition, the formation of psoriatic lesions can be promoted by GLS1, a downstream target of MALT1 protease, mediating glutaminolysis to promote acetyl coenzyme A-induced differentiation of Th17 and Th17 cells by activating the Il17a promoters histone 3 at the lysine 9 and 27 residues (H3K9Ac and H3K27Ac) (79) ( Table 1 )

In the skin of the same vitiligo patient, the expression of MITF in the lesion skin was lower than that in the non-lesion skin [51]

16S rRNA microbiome analysis For Supplementary Fig

1180/479 Baddi (H P)

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Statistics Values are expressed as mean SD