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The work, which used the protein insulin-like growth factor-1 (IGF-1), showed that an orally delivered, shelf-stable medication grown in lettuce plants could stimulate the growth of bone-building cells and promote bone regeneration

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For a certain period of time, this could be autocatalytic, because H2O2 production in the oxidative burst requires a continuous Ca2+ influx, which activates the plasma membrane-localized NADPH oxidase (Lamb and Dixon, 1997