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the antibody generated by introducing substitutions in the VH domain, VH CDRs, VL domain and/or VL CDRs of an ADC of 12G3H11, Eph099B-102.147, B208, B210, B233, EA2, EA3, EA4, EA5, 10C12, 4H5, 10G9, 3F2, 1C1, 1F12, 1H3, 1D3, 2B12, 5A8, 5A8LX-13 or scFv EA44 can be tested in vitro and in vivo, for example, for its ability to bind to an Eph receptor (by, e.g., immunoassays including, but not limited to ELISAs and BIAcore), or for its ability to mediate, prevent, treat, manage or ameliorate cancer or one or more symptoms thereof

doi: 10.1016/j.clim.2016.04.007 85 SuJHuaXConchaHSvenungssonECederholmAFrostegardJ

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