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Since the peroxisome is the center of H 2 O 2 synthesis because of fatty acid -oxidation, photorespiration, oxidative stress, and purine catabolism, they are mostly present there [21]

In comparison with polyP solution, the observed relatively decreased intensity of band at 1156.75 cm 1 (PO 2 ) and 688.26 cm 1 (POP) in the polyP-Mn might be attributed to binding effect of Mn ion with the internal PO 2 of polyP chain

It was demonstrated that Ro52/SSa is a signaling molecule sensitive to H 2 O 2 that is capable of translocating from the cytoplasm to the nucleus in the MAP kinase (MAPK) pathway (Nobuhara et al., 2007)

Shindo Y, Witt E, Packer L

Oxidative Stress and Neuroinflammation Probing the Pathophysiology of ME/CFS through Neuroimaging The discovery of ME/CFS-specific biomarkers that can advance our understanding of the illness and its pathogenic mechanisms, differentiate the disorder from overlapping or comorbid diagnoses, and identify potential treatment targets is currently a pressing and unmet research and public health need

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