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Description

Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells

They can also induce cell cycle arrest by altering cyclins and CDKs

A second problem for apprehending PAIS is that, whatever the initial etiology, chronicity implies mechanisms of self-perpetuation, not in a steady way, but involving in most cases flares and remissions