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Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

In people with T2D, 48% of the participants achieved 10% WL after 26 weeks of treatment with orforglipron 45 mg in a phase 2 trial (Fig

Also, much attention has been paid on glymphatic system [87] and intramural peri-arterial drainage pathway [88], by which misfolded/aggregated proteins in interstitial fluid (ISF) of the brain and spinal cord could be drained into cerebrospinal fluid (CSF) and then cleared [89]

Sternke M, Tripp KW, Barrick D (2019) Consensus sequence design as a general strategy to create hyperstable, biologically active proteins

127 TakumidaM.AnnikoM

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