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AJNR 17:365373 Robert P et al (2015) T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents

Patients with known or suspected mitochondrial disease: Valproate induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase (POLG) (e.g., Alpers-Huttenlocher Syndrome) at a higher rate than those without these syndromes (see Contraindications)

Human pluripotent stem cell-derived intestinal organoids for pharmacokinetic studies

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Freie Radikale reagieren mit normalen Zellstrukturen, wodurch die Zellen geschdigt werden und der Zelltod hervorgerufen werden kann