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Am J Cardiovasc Dis 1:293311 Pierno S, Desaphy JF, Liantonio A, De Bellis M, Bianco G, De Luca A et al (2002) Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

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It also activates the Nrf2 pathway, which upregulates antioxidant enzymes like CAT, SOD2, and HO-1, strengthening the cellular response to oxidative stress 197,199