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Researchers have been seeking relevant strategies and specific autophagy modulators for treating BPH

Research has found that the E3 ubiquitin ligase Peli1 is activated by ATM-mediated phosphorylation, promoting the ubiquitination of NBS1 and enhancing the accumulation of ATM and the MRN complex at DSB sites [316, 317]

Notably, a clinical trial (NCT00731731) investigated the combination of Volinostat, Temozolomide, and radiotherapy for early treatment of glioblastoma multiforme has been reported