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Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)

among those, GTPases or their activators/inhibitors (Tiam-1 - T-cell lymphoma invasion and metastasis-inducing protein 1, Rho-C - Ras homolog gene family, member C), and receptor tyrosine kinase (RTK) upstream of Rho GTPases as hepatocyte growth factor receptor (HGFR/c-Met) or tyrosine kinase receptor (Trk-A) [22]

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Whether dihydrolipoic acid effectively regenerates antioxidants under physiological conditions is unclear (3)

Flexibility exists, but precision correlates directly with results