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[76] demonstrated that curcumin suppressed HCC CSCs via inhibition of the PI3K/Akt/mTOR signaling pathway

Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA

Thanks to rapid progress in the study of ferroptosis, numerous efforts have made to identify potent, druggable ferroptosis modulators for use in clinical applications, opening new avenues for developing novel treatment strategies to target many ferroptosis-related diseases, including cancer and heart injury

If other vitamin deficiencies are present, they should be treated

LC3-II and Beclin-1 are key molecules in the autophagy pathway, induction of HO-1 activates the autophagy pathway by increasing the expression of LC3-II and Beclin-1, thereby removing harmful substances from cardiomyocytes [108]

AMP-activated protein kinase (AMPK) signaling pathway GPER enhances energy metabolism by activating AMPK, a key regulator of obesity and metabolic diseases