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1 H NMR (400 MHz, CDCl 3 ) 8.94 (t, J = 5.3 Hz, 2H, NH 2), 7.887.62 (m, 30H, ArH 30), 3.843.67 (m, 8H, H 2 -1 2 and H 2 -6 2), 3.07 (dd, J = 11.7, 5.8 Hz, 4H, H 2 -2 2), 1.871.76 (m, 4H, H 2 -4 2), 1.711.49 (m, 8H, H 2 -3 2 and H 2 -5 2)

(1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion

doi: 10.20546/ijcmas.2019.803.224 113 KhanM.KhanT.TabassumB.HashimM

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Psoriasis involves uncontrolled activation of T helper cells (Th1) and (Th17), resulting in the overproduction of pro-inflammatory cytokines, such as IL-1, IL-6, IL-23, IL-22, interferon alpha (IFN-), and TNF- (204206)

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Wilkes J.G., Alexander M.S., Cullen J.J