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Secondary antioxidants are externally provided from dietary sources, such as vitamins (vitamins A, C and E), minerals (selenium, zinc, copper and manganese) and other substances, including polyphenols found in grapes and green tea

Therapeutic interventions targeting the gut microbiota, such as probiotics, prebiotics, postbiotics, and fecal microbiota transplantation (FMT), have shown promise in restoring Treg-mediated immune homeostasis and ameliorating inflammation in both intestinal and extraintestinal contexts (88, 91)

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Table 2 Traits significantly associated with the DKK3 Gene identified by PheWAS analysis

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