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Similarly, Hosohata et al

doi: 10.1007/s12272-020-01273-8 44 HassanniaBWiernickiBIngoldIQuFVan HerckSTyurinaYYet al

Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-(high) immunophenotypes: potential benefits of calcitriol

Another limitation observed was that BA-LRA scores were biased toward P450-mediated bioactivation compared to drugs that form reactive CoA-thioesters or unstable acyl-glucuronides

PMID: 36073772

In summary, the failure of the endogenous antioxidant defense system allows the massive oxidative insult to trigger a complex array of downstream pathological consequences, including robust inflammatory responses, multiple forms of cardiomyocyte death, and widespread disruption of vital signaling networks