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However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials

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As current available antiviral therapies are rarely effective in treating HBV, a group of novel antiviral drugs with distinct mechanisms are being developed, which can be categorized into the following two classes: Direct-acting antivirals that further block viral replication and lower the viral antigen load, and immunomodulators that boost immunity and restore anti-HBV immune surveillance