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Current diagnostic and therapeutic approaches under the reactive medicine paradigm demonstrate limited efficacy in controlling disease progression

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Lactate isotopologue peaks were integrated using the MATLAB-based PIRAMID software (55), and the integrated ion counts were normalized to the protein content of the cell extract samples

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The permeability study demonstrated enhanced BBB (in vitro model) permeability mediated by lactoferrin receptor-targeted transcytosis, showing a 2.7-fold increase in fluorescence intensity for lactoferrin-conjugated nanoparticles compared to non-functionalized ones