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However, the study using incremental doses of APAP demonstrated that, although Il-6 was induced and Stat-3 was activated after a moderately toxic dose and a regenerating dose of APAP, activation of Il-6/Stat-3 signaling was even higher and sustained after a severely toxic dose of APAP, in which liver regeneration was impaired

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The measurement of antioxidant index and myeloperoxidase activity in the lung homogenate Biochemical assays were carried out in the supernatants of homogenates of lung tissues and A549 cell samples