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Two decades later, Kovalzon and Strekalova (2006) [6] were equally direct, calling DSIP a still unresolved riddle and noting that the connection between the peptide and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. That framing has not materially changed in the literature since

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Both medications carry a significant risk of abuse, physical dependence, and addiction that patients and caregivers must take seriously

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Payers reimburse specific codes at full contracted rates and scrutinize unspecified ones, especially D64.9

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