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Conservative treatment with rest, ice, and physical therapy works for 70% of minor tears, while bucket-handle or complex tears often require arthroscopic surgery within 6-8 weeks to prevent further joint damage

However, another similar study evaluating the effect of hesperidin supplementation (450 mg/day for 6-weeks) in volunteers with overweight or obesity found no significant improvement at an endothelial level

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The latter ones were also identified in this study as upregulated, among them Toll-like receptors (TLR2 and TLR8, IKBKB, PIK3R1, IRF5), proteins involved in NOD-like and RIG-I-like (DDX3X, ISG15, TRIM25, TMEM173, IL18, MAVS, OAS3, PKN1, NAIP) and MAPK signaling pathways (MAPK1, MAPK10, MAP2K1, CASP, ARRB, MAX, JNK, MEK1, ERK, RSK2, IKK) as well as scavenger receptors (CD68, CD44) (Supplementary Table S3)