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A third form of constitutional erythrocytosis is caused by mutation of EGLN1 (for egl nine homolog 1), located on chromosome 1q42.1

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MtDNA inheritance patterns and sex-specific hormonal influences on mitochondrial function could contribute to this sexual dimorphism [22]

LC patients are presented with a distinct metabolomic profile compared to R, HC, and acute COVID-19 patients A total of 2584 metabolites were detected from 75 plasma samples including LC n=30, acute n=15, R n=15, and HC n=15

In combination with the existing literature (14, 15, 24, 26, 27), these results suggest that AA147 induces transient ATF6 activity broadly across cell types, whereas AA147-dependent NRF2 activation may only be observed in select cell types including the neuronal-derived HT22 and IMR32 cells

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