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In a phase II study, nilotinib and dasatinib are currently being studied in an ongoing phase IB trial as repurposed drugs [137]

In recent years, with the advancement of related research, we have learned that LAM can activate the Toll-like receptor 2 of cells, thereby activating the downstream MyD88-dependent pathway, triggering the nuclear translocation of NF-B, and inducing the expression of immune response gene 1 (Irg1) to promote the release of cellular inflammatory mediators, such as interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17A (IL-17A), tumor necrosis factor (TNF-), and granulocyte-macrophage colony-stimulating factor (GM-CSF), etc (4245)

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Moriguchi, M

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