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Under normal conditions low levels of ROS production are counteracted by antioxidants such as glutathione synthetase, superoxide dismutase or catalase, but excess ROS can lead to lipid peroxidation and apoptosis by increasing mitochondrial membrane permeability and inhibition of the mitochondrial respiratory chain (Tezel and Yang, 2004

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When the body experiences sudden changes in weight, the skin is unable to adjust quickly enough, causing it to stretch or contract abruptly