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This might be due to microbial changes

doi:10.1055/s-0040-1715428

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

doi:10.4161/auto.36184

J Nat Prod Res

2 Literature search strategy This review employed a systematic literature search methodology, searching databases including PubMed, Web of Science, Embase, and China National Knowledge Infrastructure (CNKI), with a search period from database inception to November 2024