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However, AARS is an exception, which relies on lactate-AMP as an intermediate to directly transfer lactyl group to the lysine residues of target proteins with the assistance of ATP [25, 26] As the most well-studied writer, p300-catalyzed lactylation mainly promotes gene transcription [28,29,30,31,32,33,34,35,36,37,38,39] and maintains normal protein structure and functions [40,41,42,43,44,45]

In support of direct nose-to-brain drug/cell delivery for more effective PD treatment 19,20 , we propose that mitochondria may be a useful intranasal delivery system for non-invasive clinical treatment

Imbalances in the GSH system can contribute to the development of retinal diseases, such as age-related macular degeneration, glaucoma, diabetic retinopathy, and retinitis pigmentosa (RP)

Hence, GSH may interact with the epigenome on multiple levels

Debenzylation of 3-PBLG 3-armed poly(l-glutamic acid (3-PLG) nanocarriers were synthesized by using trimethylsilyl iodide (TMSI) to debenzylate 3-PBLG (Fig

If someones homocysteine level is elevated above 10 umol/L, there is one MTHFR mutation