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doi: 10.3389/fimmu.2026.1705839 Received 15 September 2025 Revised 07 March 2026 Accepted 09 March 2026 Published 30 March 2026 Volume 17 - 2026 Edited by Nirianne Querijero Palacpac, Osaka University, Japan Reviewed by Alba Marina Gimenez, University of So Paulo, Brazil Urszula Krzych, Walter Reed Army Institute of Research, United States Updates Copyright 2026 Tandel, Thakkar, Ahuja, Shah, Trivedi, Pied, Singh, Prajapati, Tyagi and Dalai

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Meanwhile, the activity of nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases Sirtuins [especially sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3)] decreases due to NAD + depletion, leading to hyperacetylation of multiple target proteins, which tends to enhance NF-B signaling and inhibit fatty acid oxidation (52, 53)

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