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SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer

Cell 4 , 119129 (2003)

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

Consumers were advised not to use the products and seek a full refund

If things become severe, skin problems like dark spots or dryness may also show up

Serious adverse effects have not been widely reported, but long-term safety data in humans is lacking